Prophylactic Mastectomy

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Prophylactic mastectomy is a good option for patients who are at high risk of developing breast cancer. In certain situations, prophylactic mastectomy can reduce the risk of developing breast cancer by 90%-95%. 

If any of the following apply to you, you are a candidate for prophylactic mastectomy:

  • a positive test for a genetic mutation that predisposes to breast cancer (eg BRCA1, BRCA2, PALB2, CDH1, PTEN, or TP53)
  • several family members who developed breast cancer (including mother, sister, or daughter), especially before age 50
  • a particularly aggressive or invasive breast cancer
  • high risk histology on biopsy (eg "invasive lobular" disease or "lobular carcinoma in situ")
  • multiple tumors in the same breast
  • very young age at the time of the first breast cancer diagnosis
  • chest radiation before age 30 

In patients undergoing mastectomy for breast cancer, prophylactic mastectomy of the other breast can be performed at the same time, or any time later. The best timing for the prophylactic surgery depends on the patient's clinical situation, overall treatment plan and preferences.

In patients who do not have an existing breast cancer diagnosis but are at high risk, prophylactic mastectomy of both breasts is always performed at the same time. 

Nipple Sparing Mastectomy which preserves the entire breast skin envelope and natural nipple-areola is also frequently an option and should be discussed with your plastic surgeon. 

For patients choosing to have breast reconstruction, the best cosmetic results are achieved when the reconstruction is performed at the same time as the mastectomies ("immediate reconstruction"). Several breast reconstruction options can be performed in conjunction with prophylactic mastectomy including:

- using your own tissue (DIEP flapSIEA flapGAP flapTUG flapLatissimus flap)

Tissue Expander/Implant

Direct to Implant

To learn if you are a prophylactic mastectomy candidate or to schedule a consultation, please contact us here or call us on (800) 692-5565.

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Prophylactic mastectomy decreases breast cancer in high risk patients

PRMA Plastic Surgery